Group A Streptococcus induces less p65 nuclear translocation and non-classical nuclear factor kappa B activation in macrophages, which possibly leads to a weaker inflammatory response
详细信息 查看全文
- 作者：Shuhui Wua ; b ; 1 ; Cuiqing Maa ; 1 ; Xue Gaoa ; Ling Zhanga ; Qingfeng Miaoa ; Miao Lia ; Wenjian Lia ; Xiaotian Songa ; Xiurong Wanga ; Jianguo Liuc ; Lin Weia ; weilin501@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Group A Streptococcus (GAS) ; Macrophage ; Proinflammatory cytokines ; NF-κB
- 刊名：International Journal of Infectious Diseases
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：50-60
- 全文大小：2467 K
文摘
- listitem" id="list_lis0005">
- •
The inflammatory mediators in macrophages induced by group A Streptococcus (GAS) were examined.
- •
GAS induced less inflammatory mediators than Staphylococcus aureus or Escherichia coli.
- •
GAS induced less p-p65 of nuclear factor kappa B (NF-κB) translocation in macrophages than S. aureus.
- •
GAS induced non-classical NF-κB activation in macrophages: p65–p52 heterodimer.