Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates
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- 作者：Takuji Kawamura1 ; Shigeru Miyagawa1 ; Satsuki Fukushima1 ; Akira Maeda2 ; Noriyuki Kashiyama1 ; Ai Kawamura1 ; Kenji Miki3 ; Keisuke Okita3 ; Yoshinori Yoshida3 ; Takashi Shiina4 ; Kazumasa Ogasawara5 ; Shuji Miyagawa2 ; Koichi Toda1 ; Hiroomi Okuyama2 ; Yoshiki Sawa1 ; sawa-p@surg1.med.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：8 March 2016
- 年：2016
- 卷：6
- 期：3
- 页码：312-320
- 全文大小：3455 K
文摘
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Cardiomyocytes from iPSCs can treat heart disease
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iPSC-CMs were transplanted into MHC-matched or unmatched cynomolgus macacques
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Matched iPSC-CM grafts had better survival and less host rejection immune response
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Immunosuppression was still required for successful allogeneic iPSC-CM engraftment