The feasibility of a Box isolation strategy for non-paroxysmal atrial fibrillation in elderly patients

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• 作者：Satoshi Higuchi ; MD^a ; Hiroshi Sohara ; MD ; PhD^a ; ^{hysohara@uranus.dti.ne.jp" class="auth_mail" title="E-mail the corresponding author} ; Yoshinori Nakamura ; MD ; PhD^a ; Minoru Ihara ; MD ; PhD^a ; Yoshio Yamaguchi ; MD ; PhD^a ; Morio Shoda ; MD ; PhD^b ; Nobuhisa Hagiwara ; MD ; PhD^b ; Shutaro Satake ; MD ; PhD^a
• 关键词：Atrial fibrillation ; Catheter ablation ; Box isolation ; Elderly patient ; Typical atrial flutter
• 刊名：Journal of Arrhythmia
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：32
• 期：3
• 页码：198-203
• 全文大小：523 K

文摘

Catheter ablation of non-paroxysmal atrial fibrillation (non-PAF) is a therapeutic challenge especially in elderly patients. This study describes the feasibility of a posterior left atrium isolation as a substrate modification in addition to pulmonary vein isolation, the so-called Box isolation, for elderly patients with non-PAF.

Methods

Two hundred twenty-nine consecutive patients who underwent Box isolations for drug-refractory non-PAF were divided into two groups according to their age; younger group comprising 175 patients aged <75 years and elderly group comprising 54 patients aged ≥75 years.

Results

During 23.7±12.0 months of follow-up, the arrhythmia-free rates after one procedure were 53.1% in younger group versus 48.1% in elderly group (p=0.50). Following the second procedure, all patients had electrical conduction recoveries along the initial Box lesion. However, a complete Box re-isolation was highly established in both age groups (87.1% vs. 92.9%, respectively; p=1.00). Recurrence of macro-reentrant atrial tachycardia was mainly associated with the gaps through the initial Box lesion in both age groups (25.8% vs. 21.4%, p=1.00), but typical cavo-tricuspid isthmus (CTI) dependent atrial flutter was significantly observed in the elderly patients’ group only (all events were observed within 6 months after the initial procedure; 3.2% vs. 28.6%, p=0.009). After two procedures, the arrhythmia-free rates increased to 73.1% in younger group versus 66.7% in elderly group (p=0.38). The occurrence rate of procedural-related complications did not differ between the two age groups, and there were no life-threatening complications even in elderly patients.

Conclusions

Box isolation of non-PAF is effective and safe even in elderly patients. A prophylactic CTI ablation combined with Box isolation might be feasible to improve the long-term outcome.