• 作者：Coralie Varoquier ; Jean-Hugues Salmon ; Jean Sibilia ; Jacques-É ; ric Gottenberg ; ^{jacques-eric.gottenberg@chru-strasbourg.fr}
• 关键词：Syndrome de Gougerot-Sjö ; gren ; Xé ; rostomie ; Xé ; rophtalmie ; Critè ; res diagnostiques AECG ; Critè ; res diagnostiques ACR ; Anticorps anti-SSA (Ro) et anti-SSB (La) ; Biopsie des glandes salivaires accessoires
• 刊名：Revue du Rhumatisme Monographies
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：80
• 期：1
• 页码：20-25
• 全文大小：749 K

Sj?gren's syndrome is a frequent autoimmune disease but its diagnostis is sometimes diffcult and delayed, because of miscellaneous symptoms. The most frequent clinical features include oral and ocular dryness, asthenia and pain. However, extraglandular manifestations concern one third of patients and severe complications, such as lymphoma, can reveal the disease. American European Consensus Group Criteria are used in current practice. They take into account subjective and objective clinical parameters and immunological and histological criteria. New criteria, recently proposed by the ACR, take into account objective ocular dryness, salivary lymphocytic infiltrates and the presence of immunological abnormalities (antinuclear and rheumatoid factors or anti-SSA/SSB). Primary Sj?gren's syndrome must continue to benefit from a consensual diagnostic approach to ensure the quality of basic and clinical research and the applicability of their results to all patients. A group of international experts are currently working to reach a new consensus for the diagnosis of the disease.