Systemic TNF-α produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration
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- 作者：Edel Hennessy ; Shane Gormley ; Ana Belen Lopez-Rodriguez ; Caoimhe Murray ; Carol Murray ; Colm Cunningham ; colm.cunningham@tcd.ie
- 关键词：TNF-α ; Systemic inflammation ; Microglia ; Sickness ; Behavior ; Dementia ; Delirium
- 刊名：Brain, Behavior, and Immunity
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：59
- 期：Complete
- 页码：233-244
- 全文大小：2336 K
- 卷排序：59
文摘
Mice with prior hippocampal neurodegeneration are more susceptible to systemic TNF-α, displaying: Acute working memory deficits not present in normal animals similarly challenged. Exaggerated sickness behavior with respect to normal TNF-challenged animals. Heightened brain expression of TNF-α mRNA and IL-1β mRNA and protein.