Regulators in the apoptotic pathway during spermatogenesis: Killers or guards?
详细信息 查看全文
- 作者：Ya-Ru Xu ; Hong-Shan Dong ; Wan-Xi Yang ; wxyang@spermlab.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：GCs ; germ cells ; FasL ; Fas ligand ; SCF ; stem cell factor ; FGF ; fibroblast growth factor ; TGF ; transforming growth factor ; FSH ; follicle stimulating hormone ; LH ; luteinizing hormone ; E2 ; estrogen ; MIS ; Mü ; llerian inhibiting substance ; SCs ; Sertoli cells ; GnRH ; gonadotropin-releasing hormone ; T ; testosterone ; Bcl-2 ; B-cell lymphoma 2 ; TNF ; tumor necrosis factor ; FADD ; Fas associated death domain ; TRAIL ; TNF-related to apoptosis-inducing ligand ; DISC ; death-inducing signaling complex ; cytC ; cyt
- 刊名：Gene
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：582
- 期：2
- 页码：97-111
- 全文大小：1579 K
文摘
- •
Classic apoptotic pathways during spermatogenesis are summarized.
- •
Kinds of apoptosis and survival factors during spermatogenesis are reviewed.
- •
Functions of four testis apoptosis related genes are elucidated.
- •
Molecular mechanisms with stress inducers (heat, hyperglycemia) are clarified.
- •
Roles, functions and possible connections among diverse factors are discussed.