Highly expressed lncRNA CCND2-AS1 promotes glioma cell proliferation through Wnt/β-catenin signaling

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• 作者：Hua Zhang^a ; Dai-Lin Wei^b ; Long Wan^c ; Shao-Feng Yan^a ; Yan-Hui Sun^a ; ^{pekingtiantan@126.com}
• 关键词：LncRNA CCND2-AS1 ; Wnt/β-catenin signaling ; Glioma
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1219-1225
• 全文大小：1380 K
• 卷排序：482

文摘

LncRNA CCND2-AS1 was significantly upregulated in glioma cancer tissues and cell lines. Overexpression CCND2-AS1 confers a poor prognosis in glioma patients. Knockdown of CCND2-AS1 inhibited glioma cell proliferation and induced cell cycle arrest. Overexpression CCND2-AS1 promotes cell growth in Normal human astrocyte (NHA). LncRNA CCND2-AS1 regulates the activation of Wnt/β-catenin signaling in glioma cells.