Genetic disruption of tubulin acetyltransferase, αTAT1, inhibits proliferation and invasion of colon cancer cells through decreases in Wnt1/β-catenin signaling

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• 作者：Somi Oh ; Eunae You ; Panseon Ko ; Jangho Jeong ; Seula Keum ; Sangmyung Rhee ; ^{Sangmyung.rhee@cau.ac.kr}
• 关键词：Microtubule acetylation ; Colon cancer ; Invasion ; Wnt1 ; αTAT1 ; HDAC6
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：482
• 期：1
• 页码：8-14
• 全文大小：1552 K
• 卷排序：482

文摘

Ablation of αTAT1 inhibits HCT116 colon cancer cell invasion. αTAT1/acetylated microtubules regulate expression of Wnt1/β-catenin target genes. Acetylated microtubules regulate cellular localization of β-catenin. Loss of αTAT1 prevents Wnt1 from inducing β-catenin-dependent and -independent pathways.