Epigenetic silencing of HOPX contributes to cancer aggressiveness in breast cancer
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- 作者：Mariko Kikuchi1 ; Hiroshi Katoh1 ; Mina Waraya ; Yoko Tanaka ; Satoru Ishii ; Toshimichi Tanaka ; Nobuyuki Nishizawa ; Keigo Yokoi ; Naoko Minatani ; Akira Ema ; Yoshimasa Kosaka ; Hirokazu Tanino ; Keishi Yamashita ; Masahiko Watanabe ; intl-aff@kitasato-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：HOPX ; Breast cancer ; Epigenetic silencing ; HER2
- 刊名：Cancer Letters
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：384
- 期：Complete
- 页码：70-78
- 全文大小：2246 K
文摘
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Promoter methylation is the critical mechanism for epigenetic silencing of HOPX in breast cancer.
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HOPX promoter methylation is cancer-specific and frequent event in human breast cancer.
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HOPX promoter methylation independently predicts worse prognosis of breast cancer patients.
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HOPX promoter methylation was closely associated with HER2 positivity.