ERβ up-regulation was involved in silibinin-induced growth inhibition of human breast cancer MCF-7 cells
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- 作者：Nan Zhenga ; Lu Liua ; Weiwei Liua ; Ping Zhanga ; Huai Huanga ; Linghe Zanga ; Toshihiko Hayashia ; Shin-ichi Tashirob ; Satoshi Onoderac ; Mingyu Xiaa ; xmywd@vip.sina.com" class="auth_mail" title="E-mail the corresponding author ; Takashi Ikejimaa ; ikejimat@vip.sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Silibinin ; Estrogen receptor beta (ERβ) ; ER-β antagonist (PHTPP) ; ER-β agonist (DPN) ; Apoptosis ; Autophagy
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：591
- 期：Complete
- 页码：141-149
- 全文大小：2566 K
文摘
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ERβ up-regulated by silibinin caused MCF-7 cell death.
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ERβ induced caspase-9-mediated mitochondrial intrinsic apoptosis.
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ERβ was not involved in regulation of autophagic process.