P2 receptors in cancer progression and metastatic spreading
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- 作者：Francesco Di Virgilio fdv@unife.it" class="auth_mail" title="E-mail the corresponding author ; Simonetta Falzoni ; Anna Lisa Giuliani ; Elena Adinolfi
- 刊名：Current Opinion in Pharmacology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：29
- 期：Complete
- 页码：17-25
- 全文大小：930 K
文摘
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Extracellular ATP and adenosine activate specific receptors on host and tumor cells.
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Host adenosine (A2A) receptor activation causes immunosuppression.
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Host adenosine (A2A) receptor blockade inhibits tumor growth.
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Most tumors overexpress selected ATP receptor subtypes, namely P2X7.
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Pre-clinical data show that P2X7 targeting has a potent anti-tumor effect.