Simple mechanisms of early life - simulation model on the origin of semi-cells

详细信息    查看全文

• 作者：Adrian Klein^a ; ^{adrian@uni-bonn.de} ; Martin Bock^b ; Wolfgang Alt^b
• 关键词：Origin of life ; Evolution ; Particle dynamics ; Iron-sulfur theory ; Lipid bilayer ; Proto-cell
• 刊名：Biosystems
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：151
• 期：Complete
• 页码：34-42
• 全文大小：7684 K
• 卷排序：151

文摘

The development of first cellular structures played an important role in the early evolution of life. Early evolution of life probably took place on a molecular level in a reactive environment. The iron-sulfur theory postulates the formation of cell-like structures on catalytic surfaces. Experiments show that H2S together with FeS and other metallic centers drive auto-catalytic surface reactions, in which organic molecules such as pyruvic and amino acids occur. It is questionable which mechanisms are needed to form cell-like structures under these conditions. To address this question, we implemented a model system featuring the fundamentals of molecular dynamics: heat, attraction, repulsion and formation of covalent bonds. Our basic model exhibits a series of essential processes: self-organization of lipid micelles and bilayers, formation of fluid filled cavities, flux of molecules along membranes, transport of energized groups towards sinks and whole colonies of cell-like structures on a larger scale. The results demonstrate that only a few features are sufficient for discovering hitherto non described phenomena of self-assembly and dynamics of cell-like structures as candidates for early evolving proto-cells.Significance statementThe quest for a possible origin of life continues to be one of the most fascinating problems in biology. In one theoretical scenario, early life originated from a solution of reactive chemicals in the ancient deep sea, similar to conditions as to be found in thermal vents. Experiments have shown that a variety of organic molecules, the building blocks of life, form under these conditions. Based on such experiments, the iron-sulfur theory postulates the growth of cell-like structures at certain catalytic surfaces. For an explanation and proof of such a process we have developed a computer model simulating molecular assembly of lipid bilayers and formation of semi-cell cavities. The results demonstrate the possibility of cell-like self-organization under appropriate physico-chemical conditions.