Three-step channel conformational changes common to DNA packaging motors of bacterial viruses T3, T4, SPP1, and Phi29

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• 作者：Shaoying Wang^a ; ^b ; Zhouxiang Ji^a ; ^b ; Erfu Yan^b ; Farzin Haque^a ; ^b ; Peixuan Guo^a ; ^b ; ^{guo.1091@osu.edu}
• 关键词：Nanotechnology ; Nanobiotechnology ; Viral assembly ; Nanomotor ; Biomotor ; Single channel conductance ; Nanopore ; Nano channel
• 刊名：Virology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：500
• 期：Complete
• 页码：285-291
• 全文大小：2048 K
• 卷排序：500

文摘

All portal channels from T3, T4, SPP1, and phi29 bacteriophage have inserted into lipid bilayer. All these portal channels exercise three discrete steps of gating, as revealed by single channel electrophysiological assay. The three steps of gating coincide with the three major steps of quantized DNA packaging as reported previously; suggesting that the one way inbound channel during the DNA packaging process is transformed into an outbound channel prepared for DNA ejection during the host infection.