Sinomenine attenuates renal fibrosis through Nrf2-mediated inhibition of oxidative stress and TGFβ signaling
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- 作者：Tian Qina ; Shasha Yinb ; Jun Yangb ; Qin Zhangb ; Yangyang Liub ; Fengjie Huanga ; hfj@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wangsen Caob ; wangsencao@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ROS ; reactive oxygen species ; UUO ; unilateral ureteral obstruction ; HE ; hematoxylin and eosin ; SIN ; sinomenine ; LPS ; lipopolysaccharide ; TGFβ ; transforming growth factorβ ; Nrf2 ; nuclear factor-erythroid 2 (NF-E2)-related factor ; Keap1 ; Kelch-like ECH-associated protein 1 ; HO-1 ; heme oxygenase-1 ; NQO1 ; NAD(P)H ; quinoneoxidoreductase 1 ; EMT ; epithelial-myofibroblast transdifferentiation ; ECM ; extracellular matrix ; TNF-α ; tumor necrosis factor-α ; NOS2 ; nitric oxide synthase 2 ; SOD ; superoxide dismu
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：304
- 期：Complete
- 页码：1-8
- 全文大小：1710 K
文摘
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Sinomenine has strong potency of inhibiting renal fibrosis in UUO mouse kidney.
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Sinomenine attenuates the expression of profibrogenic proteins.
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Sinomenine balances renal fibrosis-associated oxidative stress.
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Sinomenine mitigates profibrogenic signaling of TGBβ/Smad and Wnt/β-catenin.
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Sinomenine exerts anti-renal fibrotic functions mainly via activating Nrf2 pathways.