Enhancing percutaneous permeability of sinomenine hydrochloride using dual-frequency sonophoresis

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• 作者：L. Yin^a ; ^b ; F.H. Qin^a ; ^b ; Y. Zhou^c ; X. Qi^a ; ^b ; ^{yinliang@mail.buct.edu.cn}
• 关键词：Transdermal drug delivery ; Dual frequency ; Sonophoresis ; Sinomenine hydrochloride ; Cavitation ; Ultrasound
• 刊名：Journal of Drug Delivery Science and Technology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：36
• 期：Complete
• 页码：62-67
• 全文大小：764 K
• 卷排序：36

文摘

The objective of this study was to test whether dual-frequency ultrasound could enhance the efficacy of sonophoresis and whether the enhanced effect of dual-frequency was additive or synergistic. The enhancing percutaneous permeability of sinomenine hydrochloride was studied and the mechanism behind transdermal delivery enhancement via dual-frequency sonophoresis was analyzed by employing dual-frequency of 20 kHz and 800 kHz. In order to simultaneously use two ultrasound probes with different frequencies to pre-treat skin and carry out permeation experiment in the same apparatus, an improved Franz diffusion cell was designed. In comparison to single-frequency (20 kHz or 800 kHz) ultrasound, the effect of dual-frequency (20 kHz + 800 kHz) ultrasound on transdermal permeation of sinomenine hydrochloride was studied. Experiments showed that using dual-frequency ultrasound, the 12-h permeability of sinomenine hydrochloride was greater than the sum of that compared to 20 kHz and 800 kHz single-frequency samples respectively. In addition, dual-frequency pretreatment could reduce minimum threshold dose of pretreatment time in this experiment. The experimental results indicated that dual-frequency ultrasound could be more efficient in enhancing transdermal and topical delivery of sinomenine hydrochloride when compared with single-frequency ultrasound and improving transdermal delivery is due to synergistic effect instead of simple energy superposition.