Local structure based method for prediction of the biochemical function of proteins: Applications to glycoside hydrolases
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- 作者：Ramya Parasuram1 ; 2 ; Caitlyn L. Mills1 ; Zhouxi Wang3 ; Saroja Somasundaram ; Penny J. Beuning ; Mary Jo Ondrechen ; mjo@neu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CAL/G ; concanavalin A-like lectin/glucanase ; GHs ; glycoside hydrolases ; POOL ; Partial Order Optimum Likelihood ; 6-HG ; six-hairpin glycosidase ; SG ; Structural Genomics ; SALSA ; Structurally Aligned Local Sites of Activity ; THEMATICS ; THEoretical Microscopic Anomalous TItration Curve Shapes ; NAG ; N-acylglucosamine
- 刊名：Methods
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：51-63
- 全文大小：1983 K
文摘
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SALSA aligns predicted functionally active residues of proteins in a superfamily.
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SALSA classifies protein functions based on predicted active spatial positions.
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Two proteins of unknown function (3ON6, 2P0V) are predicted exo-α-1,6-mannosidases.
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A putative glycoside hydrolase (2RDY) showed a good match to α-l-galactosidase.
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GH16 family member from M. smegmatis (3RQ0) is predicted to be an endoglucanase.