Pleiotropic properties of ASK1

详细信息    查看全文

• 作者：Chihiro Sakauchi¹ ; Hiroaki Wakatsuki¹ ; Hidenori Ichijo ; ^{ichijo@mol.f.u-tokyo.ac.jp} ; Kazuki Hattori
• 关键词：ASK1 ; MAPK cascade ; Apoptosis ; Oxidative stress
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3030-3038
• 全文大小：519 K
• 卷排序：1861

文摘

ASK1 responds to diverse stresses and controls a wide variety of cellular responses. ASK1 is highly sensitive to oxidative stress and contributes to apoptosis. Post-translational modifications tightly regulate ASK1 activity. ASK1 is involved in various diseases including cancer and diabetes.