Inhibitory effect of PCSK9 on Abca1 protein expression and cholesterol efflux in macrophages

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• 作者：Maria Pia Adorni^a ; Eleonora Cipollari^a ; Elda Favari^a ; Ilaria Zanotti^a ; ^{ilaria.zanotti@unipr.it} ; Francesca Zimetti^a ; Alberto Corsini^b ; Chiara Ricci^b ; Franco Bernini^a ; Nicola Ferri^c
• 关键词：PCSK9 ; Cholesterol efflux ; ABCA1 ; Macrophage
• 刊名：Atherosclerosis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：256
• 期：Complete
• 页码：1-6
• 全文大小：703 K
• 卷排序：256

文摘

PCSK9 specifically inhibits Abca1-mediated cholesterol efflux in WT, but not in Ldlr−/− macrophages. PCSK9 inhibits Abca1 protein expression in WT, but not in Ldlr−/− macrophages. PCSK9, by inhibiting cholesterol efflux process, may facilitate foam cell formation, a hallmark of atherosclerosis.