Small molecule adiponectin receptor agonist GTDF protects against skeletal muscle atrophy

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• 作者：Abhishek Kumar Singh^a ; Sonal Shree^b ; Sourav Chattopadhyay^a ; ^e ; Sudhir Kumar^c ; Anagha Gurjar^a ; ^e ; Sapana Kushwaha^a ; Harish Kumar^a ; Arun Kumar Trivedi^a ; Naibedya Chattopadhyay^d ; Rakesh Maurya^c ; Ravishankar Ramachandran^b ; Sabyasachi Sanyal^a ; ^e ; ^{sanyal@cdri.res.in}
• 关键词：GTDF ; Adiponectin ; Adiponectin receptor ; Skeletal muscle atrophy ; FoxO ; PGC-1α
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：273-285
• 全文大小：4686 K
• 卷排序：439

文摘

GTDF and gAd induce C2C12 myoblast differentiation. GTDF and gAd mitigate steroid, cytokine and starvation –induced myotube atrophy. Anti-atrophy action of GTDF and gAd involves activation of AMPK and AKT. GTDF and gAd induces PGC-1α and inhibits FoxO1 and 3. GTDF and gAd mitigate dexamethasone-induced skeletal muscle atrophy in vivo.