Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2
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- 作者：John F. Dankert1 ; 2 ; Gergely Rona1 ; 2 ; Linda Clijsters1 ; 2 ; Phillip Geter3 ; Jeffrey R. Skaar1 ; 2 ; Keria Bermudez-Hernandez1 ; 4 ; Elizabeth Sassani1 ; 2 ; David Fenyö ; 1 ; 4 ; Beatrix Ueberheide1 ; 5 ; Robert Schneider3 ; 6 ; Michele Pagano1 ; 2 ; 7 ; 8 ; michele.pagano@nyumc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：SLBP ; cyclin F ; ubiquitin ; proteasome ; apoptosis ; canonical histone mRNA metabolism ; H2A.X ; DNA damage response ; genotoxic stress
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：64
- 期：3
- 页码：507-519
- 全文大小：3222 K
文摘
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SCFcyclin F targets SLBP for proteasome-mediated degradation in G2
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Cyclin F and cyclin A2 interact with SLBP through an atypical bivalent CY motif
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Expression of SLBP in G2 leads to increased translation of H2AFX mRNA
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High H2A.X levels make cells more susceptible to apoptosis upon genotoxic stress