Developmental changes in serotonin signaling: Implications for early brain function, behavior and adaptation

详细信息    查看全文

• 作者：S. Brummelte^a ; ^{sbrummelte@wayne.edu} ; E. Mc Glanaghy^b ; ^c ; A. Bonnin^d ; T.F. Oberlander^b ; ^c
• 关键词：5-HIAA ; 5-hydroxyindoleacetic acid ; main 5-HT metabolite ; 5-HT ; 5-hydroxytryptamine ; serotonin ; EF ; executive functioning ; G  ; × ;   ; E ; Gene  ; × ;   ; Environment (interactions) ; HPA ; hypothalamic-pituitary&ndash ; adrenal ; MAO ; monoamine oxidase ; SERT ; 5-HT transporter ; SLC6A4 ; 5-HT transporter gene (Solute Carrier Family 6 ; Member 4 gene) ; s/l allele ; short/long allele ; SNRI ; serotonin-norepinephrine reuptake inhibitor ; SSRI ; selective serotonin reuptake inhibitor
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：342
• 期：Complete
• 页码：212-231
• 全文大小：881 K
• 卷排序：342

文摘

The 5HT system starts to develop early and plays a crucial role in brain maturation. Alterations in the serotonergic tone during development can change neural networks. The s and l alleles of the SERT gene are associated with different vulnerabilities. Developmental exposure to SSRIs can affect the biobehavioral outcome. The interaction of genes, environment and SSRI exposure determines risk or resilience.