SLC6A4 methylation as an epigenetic marker of life adversity exposures in humans: A systematic review of literature

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• 作者：Livio Provenzi^a ; ^{livio.provenzi@bp.lnf.it} ; Roberto Giorda^b ; Silvana Beri^b ; Rosario Montirosso^a
• 关键词：Early adversity ; Epigenetics ; Methylation ; Serotonin transporter ; SLC6A4 ; Stress ; Systematic review
• 刊名：Neuroscience & Biobehavioral Reviews
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：71
• 期：Complete
• 页码：7-20
• 全文大小：1503 K
• 卷排序：71

文摘

DNA methylation epigenetically modifies gene transcription in response to adversities. Altered DNA methylation associates to adverse socio-emotional development. The serotonin transporter gene (SLC6A4) regulates socio-emotional development. Evidence on human SLC6A4 methylation in response to adversities is reviewed. Altered SLC6A4 methylation emerged as a potential marker of adversity exposure.