Impact of infection or vaccination on pre-existing serological memory

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• 作者：Ian J. Amanna ; Erika Hammarlund ; Mathew W. Lewis ; Mark K. Slifka
• 关键词：DT ; diphtheria toxin ; EBV ; Epstein-Barr virus ; EU ; ELISA units ; HepA ; hepatitis A virus ; MV ; measles virus ; PT ; pertussis toxin ; RUBV ; rubella virus ; TLR ; toll-like receptor ; TT ; tetanus toxin C-fragment ; Typhoid ; Salmonella typhi Ty21a ; VV ; vaccinia viru
• 刊名：Human Immunology
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：73
• 期：11
• 页码：1082-1086
• 全文大小：476 K

文摘

Once established, serum antibody responses against a specific pathogen may last a lifetime. We describe a cohort of four subjects who received smallpox vaccination, and a single subject who received multiple vaccinations, with antibody levels to unrelated antigens monitored for 1-3 years. These immunizations provided the opportunity to determine if infection/vaccination and the resulting toll-like receptor stimulation would alter antigen-specific serological memory to other antigens, including bacterial toxins (tetanus, diphtheria, and pertussis) and viruses (yellow fever virus, measles, mumps, rubella, Epstein-Barr virus, and varicella-zoster virus). Our results indicate that serum IgG levels are remarkably stable and infection or vaccination are unlikely to increase or decrease pre-existing antigen-specific antibody responses.