Deterioration in physical activity and function differs according to treatment type in non-small cell lung cancer - future directions for physiotherapy management

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• 作者：C.L. Granger^a ; ^b ; ^c ; ^{catherine.granger@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author} ; S.M. Parry^a ; ^{selina.parry@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author} ; L. Edbrooke^a ; ^{larae@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author} ; L. Denehy^a ; ^c ; ^{linda.denehy@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Lung neoplasms ; Non-small cell lung cancer ; Physical activity ; Function ; Physiotherapy ; Health-related quality of life
• 刊名：Physiotherapy
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：102
• 期：3
• 页码：256-263
• 全文大小：651 K

文摘

To investigate in non-surgically and surgically treated non-small cell lung cancer (NSCLC): (1) changes in physical activity, function, health-related quality of life (HRQoL) and symptoms after diagnosis; and (2) the association between physical activity and outcomes.

Design

Prospective observational study.

Setting

Three acute tertiary hospitals.

Participants

Sixty-nine individuals (43 male, median [IQR] age 68 [61 to 74] years) with stage I–IV NSCLC.

Main outcome measures

The primary outcome (Physical Activity Scale for the Elderly) and secondary outcome (six-minute walk test and questionnaires assessing HRQoL, function, symptoms, mood) were measured at diagnosis (pre-treatment), and eight to ten weeks post-diagnosis (post-operative and/or during chemotherapy/radiotherapy).

Results

Individuals treated surgically (n = 27) experienced a deterioration in physical activity levels (baseline median [IQR] = 74 [51 to 135]; follow-up median [IQR] = 29 [24 to 73]; median difference = 45, effect size = 0.3). At follow-up physical activity was inversely related to depression, pain and appetite loss (rho > 0.5, p < 0.05). In contrast non-surgical individuals (n = 42) did not experience a change in physical activity, however did experience deterioration in function, functional capacity, global HRQoL, fatigue and dyspnoea. Physical activity levels were low in this group and at follow-up the strongest relationships with physical activity levels were global HRQoL, function, fatigue and mood (inverse, rho > 0.5, p < 0.05).

Conclusions

Surgically treated individuals experienced a reduction in physical activity levels after diagnosis, which was not seen in the non-surgical group. Lower physical activity levels were associated with poorer outcomes, particularly in non-surgically treated individuals. Further research is required to establish the optimal intervention to improve physical activity levels in these cohorts.