Predisposing role of vitamin D receptor (VDR) polymorphisms in the development of multiple sclerosis: A case-control study
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- 作者：Rasoul Abdollahzadeha ; Mahsa Sobhani Fardb ; c ; Farideh Rahmanid ; Kaveh Moloudie ; Behrooz Sadeghi kalanif ; Asaad Azarnezhada ; g ; Azarnezhad@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Multiple sclerosis ; Genetic association studies ; Vitamin D receptor ; Single nucleotide polymorphism
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：367
- 期：Complete
- 页码：148-151
- 全文大小：231 K
文摘
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The vitamin D receptor (VDR) plays a central role in vitamin D metabolism, both as a mediator of biological effects and also as the regulator of vitamin D metabolism.
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Most effects of vitamin D are mediated by the binding of 1, 25(OH) 2D to the VDR.
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VDR and its ligand have shown relative immunosuppressive and anti-inflammatory role.
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Genome-wide association studies (GWAS) suggested more than 20 loci in MS susceptibility, including VDR gene.
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The VDR polymorphisms affect its structure and function and it is believed that have a link with an increased risk of MS.