Sex-dependent effects of lead and prenatal stress on post-translational histone modifications in frontal cortex and hippocampus in the early postnatal brain
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- 作者：Jay S. Schneidera ; jay.schneider@jefferson.edu" class="auth_mail" title="E-mail the corresponding author ; David W. Andersona ; Sarah K. Kidda ; Marissa Sobolewskib ; Deborah A. Cory-Slechtab
- 关键词：H3K9/14Ac ; H3K9Me3 ; Hippocampus ; Frontal cortex ; Lead ; Prenatal stress
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：65-71
- 全文大小：757 K
文摘
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H3K9/14Ac and H3K9Me3 are suggested to be sexually dimorphic histone modifications.
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H3K9/14Ac and H3K9Me3 were examined for modification by lead and prenatal stress.
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Sex-dependent differences were seen in both histone modifications.
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Effects of lead and stress were sex and brain-region-dependent.