IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma
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- 作者：Hsuan-Yu Penga ; f ; Shih-Sheng Jianga ; Jenn-Ren Hsiaob ; Michael Hsiaoc ; Yuan-Ming Hsua ; Guan-Hsun Wua ; Wei-Min Changa ; d ; Jang-Yang Changa ; e ; Shiow-Lian Catherine Jinf ; 1 ; Shine-Gwo Shiaha ; 1 ; davidssg@nhri.org.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：microRNA ; SOCS2 ; IL-8 ; Invasion ; Oral squamous cell carcinoma
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：10
- 期：6
- 页码：895-909
- 全文大小：2862 K
文摘
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miR-424-5p is overexpressed in OSCC.
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miR-424-5p directly targets SOCS2, leading to increased cell migration and invasion.
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STAT5 activation is required for IL-8-mediated miR-424-5p transcription.
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miR-424-5p plays an important role in mediating IL-8/STAT5/SOCS2 feedback loop.
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