Suppressor of cytokine signaling 2 (SOCS2) negatively regulates the expression of antimicrobial peptides by affecting the Stat transcriptional activity in shrimp Marsupenaeus japonicus
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- 作者：Jie-Jie Sun ; Jiang-Feng Lan ; lanjiangfeng@mail.hzau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ji-Dong Xu ; Guo-Juan Niu ; Jin-Xing Wang ; jxwang@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Signal transducer and activator of transcription (Stat) ; Suppressor of cytokine signaling 2 (SOCS2) ; Antimicrobial peptides ; Shrimp
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：473-482
- 全文大小：2589 K
文摘
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SOCS2 RNAi increases Stat phosphorylation and expression of antimicrobial peptides.
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Bacterial clearance and survival rate increased in SOCS2-RNAi shrimp infected by Vibrio anguillarum.
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SOCS2 expression was regulated by Jak/Stat pathway.
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SOCS2 negatively regulates the Jak/Stat pathway in shrimp antibacterial immunity.
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