GLP-1 analogue recovers impaired insulin secretion from human islets treated with palmitate via down-regulation of SOCS2

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• 作者：Azazul Islam Chowdhury ; ^{azazul.chowdhury@mcb.uu.se} ; Peter Bergsten
• 关键词：Type 2 diabetes ; Palmitate ; GLP-1 ; SOCS2 ; PI3kinase
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：194-202
• 全文大小：1378 K
• 卷排序：439

文摘

Long term palmitate treatment up-regulates SOCS2 protein level. SOCS2 decreases PI3K activity by degrading IRS-1 protein. SOCS2 impairs GSIS and increase apoptosis which are reversed by GLP-1 analogue.