Biocompatibility of polysebacic anhydride microparticles with chondrocytes in engineered cartilage
详细信息 查看全文
- 作者：Sathish Ponnurangam
- 关键词：Articular cartilage ; Polysebacic anhydride ; Microparticles ; Delivery ; Lipotoxicity ; Hydrogel
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：136
- 期：Complete
- 页码：207-213
- 全文大小：1288 K
文摘
- titem" id="list_lis0005">
- <p id="par0005">Polysebacic anhydride (PSA) based polymeric microparticles as a delivery vehicle for sustained release of nutrients in articular cartilage tissue engineering.p>
- <p id="par0010">PSA polymer biocompatible only at concentrations below 2 mg/mL.p>
- <p id="par0015">Mechanism of cytotoxicity is intracellular accumulation of PSA—lipotoxicity.p>
- <p id="par0020">Bovine serum albumin (BSA) supplementation protects chondrocytes from PSA induced toxicityp>