Binding interactions between enantiomeric α-aminophosphonate derivatives and tobacco mosaic virus coat protein

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• 作者：Weiying Zhang ; Xiangyang Li ; Guoping Zhang ; Yan Ding ; Longlu Ran ; Liangzhi Luo ; Jian Wu ; Deyu Hu ; Baoan Song ; ^{songbaoan22@yahoo.com}
• 关键词：Interactions ; Enantiomeric α-aminophosphonate derivatives ; TMV CP ; Arg90
• 刊名：International Journal of Biological Macromolecules
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：94
• 期：part_PA
• 页码：603-610
• 全文大小：2079 K
• 卷排序：94

文摘

The binding force of enantiomeric α-aminophosphonate derivatives with TMV CP is R isomer >S isomer. Compound Q-Rinteracts with Arg90 of TMV CP through strong hydrogen bonding. Substituting arginine with glycine affects the binding affinity of the Q-Rand TMV CP. The reassembly TMV R90G virus particle resulted in a loss of its ability to infect tobacco.