Fabrication of functionalized porous silica nanoparticles and their controlled release behavior

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• 作者：Xu Zhang^a ; Yanbao Zhao^a ; ^{yanbaozhao@126.com} ; Songqiang Xie^b ; Lei Sun^a
• 关键词：Porous silica ; Nanocarriers ; Hemolytic activity ; Redox-responsive ; Drug delivery
• 刊名：Journal of Drug Delivery Science and Technology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：37
• 期：Complete
• 页码：38-45
• 全文大小：3248 K
• 卷排序：37

文摘

Thiol and amine difunctionalized porous silica (pSiO2-SH/NH2) nanoparticles (NPs) were prepared by condensation. The obtained pSiO2-SH/NH2 NPs present uniform spheres with size of 55 nm. Folic acid (FA) as a tumor targeting agent was conjugated on the surface of pSiO2 NPs by amide linkage (pSiO2-SH/FA NPs), and captopril (Cap) as test drug was used to evaluate the releasing behavior. Results indicated that Cap is easily encapsulated into the pores of pSiO2-SH/FA NPs, which can further react with the inner thiols to form disulfide bonds. The Cap release from pSiO2-Cap/FA nanocarriers can be controlled by dithiothreitol (DTT) or reduced glutathione (GSH). The pSiO2-SH/FA nanocarriers showed low cytotoxicity and redox-responsive drug release.