H2S attenuates cognitive deficits through Akt1/JNK3 signaling pathway in ischemic stroke
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- 作者：Xiangru Wena ; b ; 1 ; Dashi Qia ; 1 ; Ying Sunc ; 1 ; Xiaojing Huangd ; Fang Zhanga ; Jian Wua ; Yanyan Fua ; Kai Maa ; e ; Yang Dua ; Hongyan Donga ; YongHai Liuc ; Hongzhi Liua ; 869133848@qq.com" class="auth_mail ; Yuanjian Songa ; f ; biosongyuanjian@126.com" class="auth_mail
- 关键词：Hydrogen sulfide ; Hippocampal neuron ; Protein kinase B ; Stroke
- 刊名：Behavioural Brain Research
- 出版年：1 August 2014
- 年：2014
- 卷：269
- 期：Complete
- 页码：6-14
- 全文大小：1909 K
文摘
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Learning and memory impairments observed after brain I/R could be decreased by NaHS.
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NaHS could reduce the hippocampal CA1 neuronal injury induced by I/R.
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NaHS could inhibit the phosphorylation of ASK1 and JNK3 via phosphorylating Akt1.