Preclinical models in HNSCC: A comprehensive review

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• 作者：Benoite M&eacute ; ry^a ; ^b ; ^c ; Chlo&eacute ; Rancoule^c ; Jean-Baptiste Guy^a ; ^b ; ^c ; Sophie Espenel^a ; ^b ; ^c ; Anne-Sophie Wozny^a ; ^b ; ^d ; Priscilla Battiston-Montagne^a ; ^b ; Dominique Ardail^a ; ^b ; ^d ; Michael Beuve^e ; Gersende Alphonse^b ; ^d ; Claire Rodriguez-Lafrasse^a ; ^b ; ^d ; Nicolas Magn&eacute ; ^a ; ^b ; ^c ; ^{nicolas.magne@icloire.fr}
• 关键词：HNSCC preclinical models ; Specific cell lines ; Three-dimensional spheroid model ; Transgenic and syngeneic animal models ; In vitro and in vivo assays ; HNSCC translational research
• 刊名：Oral Oncology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：65
• 期：Complete
• 页码：51-56
• 全文大小：332 K
• 卷排序：65

文摘

Reliable experimental models are critically required in HNSCC. Immortalized cell lines represent a valuable tool widely used in HNSCC research. More sophisticated cell models such as spheroids have been developed. Appropriate animal models are an inevitable prerequisite for drug development.