Synthesis of a new class of carbinol linked bis-heterocycles via the reaction of 2-(trifluoroacetyl)chromones with indoles and pyrroles

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• 作者：Alexander V. Safrygin^a ; Roman A. Irgashev^a ; ^b ; Mikhail A. Barabanov^a ; Vyacheslav Y. Sosnovskikh^a ; ^{vy.sosnovskikh@urfu.ru" class="auth_mail" title="E-mail the corresponding author}
• 关键词：2-(Trifluoroacetyl)chromones ; Indoles ; Pyrroles ; Bis(heteroaryl)carbinols ; Pyrazoles
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：7 January 2016
• 年：2016
• 卷：72
• 期：1
• 页码：227-233
• 全文大小：667 K

文摘

2-(Trifluoroacetyl)chromones react with indoles at 90 °C under solvent-free conditions to produce the target (chromon-2-yl) (indol-3-yl) (trifluoromethyl)carbinols in 69–90% yields. In a similar manner, their reactions with pyrroles under the same conditions gave (chromon-2-yl) (pyrrol-2-yl) (trifluoromethyl)carbinols in 52–95% yields. These chromone derivatives react with 60% hydrazine hydrate in refluxing ethanol to give the corresponding pyrazoles.