Repeated unpredictable threats without harm impair spatial working memory in the Barnes maze

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• 作者：Diane J. Kim^a ; Nathan St. Louis^a ; Ralph A. Molaro^a ; Glenn T. Hudson^a ; Robert C. Chorley^a ; Brenda J. Anderson^a ; ^b ; ^{Brenda.Anderson@stonybrook.edu}
• 关键词：Stress ; Spatial working memory ; Rats ; Predator odor ; Unpredictable threat
• 刊名：Neurobiology of Learning and Memory
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：Complete
• 页码：92-100
• 全文大小：1149 K
• 卷排序：137

文摘

An ethologically relevant habitat with a simple foraging task was used to house rats for 21 days. Threats were produced by exposure to ferret dander odor, abrupt lights and sound. Repeated threats without challenges to homeostasis produced behavioral indicators of stress. After exposure to threats, spatial memory in late adolescence was impaired. Memory deficits were unlikely to result from sleep loss; circadian activity patterns were typical.