Retinoic Acid Is Sufficient for the In Vitro Induction of Mouse Spermatocytes
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- 作者：Si Wang1 ; 2 ; Xiuxia Wang1 ; Longfei Ma1 ; 3 ; Xiwen Lin1 ; Daoqin Zhang1 ; 3 ; Zhen Li1 ; 3 ; Yujian Wu1 ; Chunwei Zheng1 ; 3 ; Xue Feng1 ; 4 ; Shangying Liao1 ; Yanmin Feng1 ; 3 ; Jian Chen1 ; 3 ; Xiangjing Hu1 ; 3 ; Min Wang1 ; 5 ; Chunsheng Han1 ; hancs@ioz.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：spermatogonial stem cells ; spermatocytes ; Sertoli cells ; meiosis ; retinoic acid
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：12 July 2016
- 年：2016
- 卷：7
- 期：1
- 页码：80-94
- 全文大小：5049 K
文摘
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Retinoic acid (RA) is sufficient for the induction of spermatocytes
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RA activates meiotic genes while repressing genes for SSC self-renewal
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An in vitro model for meiosis based on RA and pup Sertoli cells is established
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Genes for meiosis have been identified using the in vitro model