The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period
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- 作者：A. Łukomskaa ; I. Baranowska-Bosiackab ; ika@pum.edu.pl" class="auth_mail" title="E-mail the corresponding author ; M. Budkowskac ; A. Pilutind ; M. Tarnowskie ; K. Deca ; B. Dołęgowskad ; E. Metrykab ; D. Chlubekb ; I. Gutowskaa
- 关键词：Lead (Pb) ; Sphingosine-1-phosphate (S1P) ; S1P receptor 1 expression ; Brain ; Prenatal Pb exposure ; Neonatal Pb exposure
- 刊名：Chemosphere
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：166
- 期：Complete
- 页码：221-229
- 全文大小：1517 K
文摘
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The blood Pb in the exposed group is higher than the control group and it is correlated with brain Pb concentration.
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Exposure to Pb is responsible for changes in the concentration of S1P in the cerebellum, prefrontal cortex and hippocampus.
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Lead exposure cause decrease expression of S1PR1 in the glial cells in the hippocampus, cerebellum and prefrontal cortex.