Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix
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- 作者：Maria P. Ikonomopouloua ; 1 ; 2 ; Jennifer J. Smitha ; 1 ; Volker Herziga ; 1 ; Sandy S. Pinedaa ; Sławomir Dziemborowiczb ; Sing-Yan Era ; Thomas Dureka ; John Gilchristc ; Paul F. Alewooda ; Graham M. Nicholsonb ; Frank Bosmansc ; Glenn F. Kinga ; glenn.king@imb.uq.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：Spider venom ; Insecticidal peptide ; Bioinsecticide ; Coremiocnemis tropix ; Lucilia cuprina ; Flystrike
- 刊名：Toxicon
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：62-70
- 全文大小：1481 K
文摘
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Two peptides (Ct1a/Ct1b) lethal to sheep blowflies were isolated from venom of the Australian tarantula Coremiocnemis tropix.
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Ct1a/1b are initially produced as prepropeptide precursors that are post-translationally processed to the mature toxins.
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Ct1a/1b may have a novel fold as the cysteine pattern does not conform to the knottin motif commonly found in spider toxins.
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Ct1a does not target insect voltage-gated sodium channels.