Increased excitability and excitatory synaptic transmission during in vitro ischemia in the neonatal mouse hippocampus
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- 作者：S.A. Zanellia ; sz5d@virginia.edu" class="auth_mail" title="E-mail the corresponding author ; K. Rajasekaranb ; karthik.rajasekaran@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author ; D.K. Grosenbaughb ; dg5kd@virginia.edu" class="auth_mail" title="E-mail the corresponding author ; J. Kapurb ; c ; jk8t@virginia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AP ; action potential ; EPSCs ; excitatory post-synaptic currents ; HCN ; hyperpolarization-activated cyclic-nucleotide-gated ; Ih ; hyperpolarization activated current ; K&ndash ; S ; Kolmogorov&ndash ; Smirnov ; mEPSCs ; miniature excitatory post-synaptic currents ; OGD ; oxygen-glucose deprivation ; Rin ; input resistance ; RMP ; resting membrane potential ; sEPSCs ; spontaneous excitatory postsynaptic currents ; TTX ; tetrodotoxin ; Vm ; membrane potential
- 刊名：Neuroscience
- 出版年：2015
- 出版时间：3 December 2015
- 年：2015
- 卷：310
- 期：Complete
- 页码：279-289
- 全文大小：1356 K
文摘
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CA1 pyramidal neurons’ membrane properties are altered during oxygen-glucose deprivation leading to increased excitability.
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Excitatory synaptic transmission is increased during both oxygen-glucose deprivation and reoxygenation.
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Excitatory postsynaptic current amplitude is unchanged indicating increased release and presynaptic mechanisms.
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These mechanisms may represent key steps in the progression from ischemic insult to acute seizure in the neonatal brain.