v-Src-induced nuclear localization of YAP is involved in multipolar spindle formation in tetraploid cells

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• 作者：Keiko Kakae^a ; Masayoshi Ikeuchi^a ; Takahisa Kuga^a ; Youhei Saito^a ; Naoto Yamaguchi^b ; Yuji Nakayama^a ; ^{nakayama@mb.kyoto-phu.ac.jp}
• 关键词：v-Src ; Tetraploidy checkpoint ; Multipolar spindle ; YAP
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：30
• 期：Complete
• 页码：19-29
• 全文大小：2388 K
• 卷排序：30

文摘

The mechanism underlying Src-induced tumorigenesis is proposed. v-Src induces abnormal cell division with multipolar spindles. v-Src prevents the nuclear exclusion of the transcription co-activator YAP