Improved assessment of sensorimotor gating in animal models relevant to ASD: A data modelling approach to quantify PrePulse Inhibition of the acoustic startle reflex

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• 作者：Sté ; phanie Degroote^a ; Darel Hunting^b ; Larissa Takser^a ; ^{larissa.takser@usherbrooke.ca}
• 关键词：ADHD ; attention deficit/hyperactivity disorder ; ASD ; autism spectrum disorders ; ATSDR ; Agency for Toxic Substances & Disease Registry ; BDE-47 ; 2 ; 2&prime ; 4 ; 4&prime ; -tetrabromodiphenyl ether ; BDE-99 ; 2 ; 2&prime ; 4 ; 4 ; 5&prime ; -pentabromodiphenyl ether ; CDC ; centers for disease control and prevention ; CNS ; central nervous system ; DBP ; dibutyl phthalate ; DEHP ; di(2-ethylhexyl)phthalate ; DiNP ; diisononyl phthalate ; G6 ; gestational day 6 ; NOAEL ; no observable adverse effect level ; P4 ; post-natal day 4
• 刊名：Journal of Neuroscience Methods
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：276
• 期：Complete
• 页码：13-22
• 全文大小：652 K
• 卷排序：276

文摘

Habituation/exhaustion occurred in all animals during PPI testing. Classic ANOVA analysis may lead to false positive effects. Mixed models and the use of a new calculation of PPI show that females Exhibit 30% less PPI compared to males. Animals exposed to VPA or EDCs do not show any deficit in PPI. Stressful test conditions and inaccurate data modeling are limiting factors for extrapolating animal PPI data to humans.