The study group comprised 114 patients with endometriosis and 92 sex-, age-, and ethnicity-matched healthy controls of Iranian ancestry. Four SNPs (rs7574865, rs7601754, rs7582694 and rs11889341) were genotyped using the MGB TaqMan.
A significant association in rs7582694 between C allele (P = 0.002, OR = 1.986, 95% CI: 1.262–3.126) and endometriosis was found in our study, while the G allele (P = 0.002, OR = 0.0503, 95% CI: 0.319–0.792) was significantly decreased in the patients population. The GC genotype (P = 0.004, OR = 2.234, 95% CI: 1.301–4.150) was also significantly overrepresented in the patients with endometriosis, while the frequency of GG genotype was significantly lower in the patient group, compared to the controls (P = 0.007, OR = 0.457, 95% CI: 0.256–0.813).
Our results for the first time showed a significant association between rs7582694 alleles and genotypes and susceptibility to endometriosis in a population.
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