White matter abnormalities in long-term anabolic-androgenic steroid users: A pilot study

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• 作者：Johanna Seitz^a ; ^e ; Amanda E. Lyall^a ; ^b ; ^e ; Gen Kanayama^c ; ^e ; Nikos Makris^a ; ^d ; ^e ; James I. Hudson^c ; ^e ; Marek Kubicki^a ; ^d ; ^e ; Harrison G. Pope Jr^c ; ^e ; Marc J. Kaufman^f ; ^e ; ^{kaufman@mclean.harvard.edu}
• 关键词：(4) ; Diffusion tensor imaging (DTI) ; Anabolic-androgenic steroids (AAS) ; Inferior-fronto-occipital fasciculus (IFOF) ; Tract-based spatial statistics (TBSS)
• 刊名：Psychiatry Research: Neuroimaging
• 出版年：2017
• 出版时间：28 February 2017
• 年：2017
• 卷：260
• 期：Complete
• 页码：1-5
• 全文大小：349 K
• 卷排序：260

文摘

Anabolic-androgenic steroids (AAS) cause psychiatric and cognitive abnormalities. We performed the first Diffusion Tensor Imaging study of long-term AAS users. Fractional anisotropy (FA) was higher in AAS users in an amygdala network tract. Among AAS users, FA in this tract was positively associated with lifetime AAS dose. The FA abnormality is consistent with prior human and animal studies of AAS effects.