Early deprivation, atypical brain development, and internalizing symptoms in late childhood

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• 作者：J. Bick^a ; ^b ; N. Fox^c ; C. Zeanah^d ; C.A. Nelson^a ; ^b ; ^e ; ^f ; ^{Charles_nelson@harvard.edu}
• 关键词：AD ; axial diffusivity ; ANOVAs ; analyses of variances ; BEIP ; bucharest early intervention project ; CAUG ; care as usual group ; DTI ; diffusion tensor imaging ; EPI ; echo planar imaging ; FA ; fractional anisotropy ; FCG ; foster care group ; HBQ ; health behavior questionnaire ; MD ; mean diffusivity ; NIG ; never institutionalized group ; RD ; radial diffusivity ; TBSS ; tract based spatial statistics
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：342
• 期：Complete
• 页码：140-153
• 全文大小：478 K
• 卷排序：342

文摘

We examined neural substrates of risk for internalizing symptoms in institutionally reared youth. Internalizing symptoms were elevated in children with histories of institutional rearing. Institutional rearing was associated with alterations in white matter throughout the brain. Tracts implicated in emotional development predicted risk for internalizing symptoms. The external capsule and body of the corpus callosum were significant mediators.