Longitudinal changes in microstructural white matter metrics in Alzheimer's disease

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• 作者：Chantel D. Mayo^a ; ^{cmayo@uvic.ca} ; Erin L. Mazerolle^b ; ^{emazerol@ucalgary.ca} ; Lesley Ritchie^c ; ^{lritchie3@exchange.hsc.mb.ca} ; John D. Fisk^d ; ^e ; ^f ; ^g ; ^{John.Fisk@nshealth.ca} ; Jodie R. Gawryluk^a ; ^{gawryluk@uvic.ca} ; for the Alzheimer's Disease Neuroimaging Initiative¹
• 关键词：AD ; Alzheimer's disease ; ADNI ; Alzheimer's Disease Neuroimaging Initiative ; DTI ; diffusion tensor imaging ; FA ; fractional anisotropy ; FSL ; Functional MRI of the Brain Software Library ; HC ; healthy controls ; MCI ; mild cognitive impairment ; MD ; mean diffusivity ; MRI ; magnetic resonance imaging ; MMSE ; Mini Mental Status Exam ; ROI ; region of interest ; TBSS ; Tract-Based Spatial Statistics ; WMS ; Wechsler Memory Scale
• 刊名：NeuroImage: Clinical
• 出版年：2017
• 出版时间：2017
• 年：2017
• 卷：13
• 期：Complete
• 页码：330-338
• 全文大小：1179 K
• 卷排序：13

文摘

Longitudinal white matter research in Alzheimer's disease. Diffusion tensor imaging used to assess microstructural white matter changes. Decreased fractional anisotropy and increased mean diffusivity over one year. Widespread changes in Alzheimer's disease include the hippocampal cingulum. DTI holds potential as Alzheimer's disease biomarker.