A Twin Study of Late-Onset Depression and Apolipoprotein E 
4 as Risk Factors for Alzheimer's Disease
4 as Risk Factors for Alzheimer's Disease
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- 作者：Steffens ; David C. ; Plassman ; Brenda L. ; Helms ; Michael J. ; Welsh-Bohmer ; Kathleen A. ; Saunders ; Ann M. ; et. al.
- 关键词：Depression ; elderly ; Alzheimer's disease ; dementia ; apolipoprotein E ; twins
- 刊名：Biological Psychiatry
- 出版年：1997
- 出版时间：April 15, 1997
- 年：1997
- 卷：41
- 期：8
- 页码：851-856
- 全文大小：615 K
文摘
A prior history of depression and the 4 allele of apolipoprotein E (APOE) have each been associated with development of Alzheimer's disease (AD). In a sample of 142 elderly twins from a large study of dementia, we examined the relation of major depression, APOE genotype and AD using time-dependent proportional hazards models. Compared against the risk for AD with no history of depression and no 4 allele, the risk ratio for AD with two 4 alleles was 2.87 (C.I. = 1.56-5.28), with one 4 allele, 1.82 (C.I. = 1.09-3.04) and with late-onset depression and no 4 allele, 2.95 (C.I. = 1.55-5.62). There was no suggestion of an interaction between prior depression and APOE genotype in their effects on AD risk. Results were similar when the sample was stratified by twin pair, so that a single genetic marker is unlikely to explain the relation among depression, APOE, and dementia. Risk ratios declined substantially with increasing intervals between the onset of depression and AD. Thus, for many individuals, the association of depression and AD may reflect the occurrence of prodromal depressive symptoms rather than a true risk relationship.
4 allele of apolipoprotein E (APOE) have each been associated with development of Alzheimer's disease (AD). In a sample of 142 elderly twins from a large study of dementia, we examined the relation of major depression, APOE genotype and AD using time-dependent proportional hazards models. Compared against the risk for AD with no history of depression and no 4 allele, the risk ratio for AD with two 4 alleles was 2.87 (C.I. = 1.56-5.28), with one 4 allele, 1.82 (C.I. = 1.09-3.04) and with late-onset depression and no 4 allele, 2.95 (C.I. = 1.55-5.62). There was no suggestion of an interaction between prior depression and APOE genotype in their effects on AD risk. Results were similar when the sample was stratified by twin pair, so that a single genetic marker is unlikely to explain the relation among depression, APOE, and dementia. Risk ratios declined substantially with increasing intervals between the onset of depression and AD. Thus, for many individuals, the association of depression and AD may reflect the occurrence of prodromal depressive symptoms rather than a true risk relationship.© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |