The role of gamma-aminobutyric acid/glycinergic synaptic transmission in mediating bilirubin-induced hyperexcitation in developing auditory neurons
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- 作者：Xin-Lu Yina ; 1 ; Min Lianga ; 1 ; Hai-Bo Shia ; Lu-Yang Wangb ; Chun-Yan Lia ; licycrystal@sina.com" class="auth_mail" title="E-mail the corresponding author ; Shan-Kai Yina ; yinshankai@china.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bilirubin ; Auditory ; Inhibitory postsynaptic current (IPSC) ; Excitotoxicity ; Patch-clamp
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：240
- 期：1
- 页码：1-9
- 全文大小：1718 K
文摘
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Bilirubin facilitates GABA/Glycinergic synaptic transmission in both bushy and stellate cells in VCN of P2-6 rats.
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Bilirubin-induced enhancement of GABA/Glycinergic transmission is Ca2+-dependent.
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Excitatory action of GABA/Glycinergic transmissions in early development is engaged in bilirubin-induced hyperexcitation and potentially contribute to high vulnerability of developing neurons to bilirubin.