CD59 Regulation by SOX2 Is Required for Epithelial Cancer Stem Cells to Evade Complement Surveillance

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• 作者：Jianfeng Chen¹ ; Peipei Ding¹ ; Ling Li¹ ; Hongyu Gu¹ ; Xin Zhang¹ ; Long Zhang¹ ; Na Wang¹ ; Lu Gan¹ ; Qi Wang¹ ; Wei Zhang¹ ; Weiguo Hu¹ ; ² ; ^{weiguohu@fudan.edu.cn}
• 关键词：CD59 ; SOX2 ; complement surveillance ; stem cells ; complement-dependent cytotoxity ; transcription regulation ; mCD59a ; mCD5b ; mouse testis
• 刊名：Stem Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：140-151
• 全文大小：3675 K
• 卷排序：8

文摘

CD59 upregulation is required for stem cells evading complement surveillance SOX2 is responsible for CD59 upregulation in stem cells SOX2 regulates mCD59b selective expression in testis spermatogonial stem cells