Standardization of Severe Sepsis Management: A Survey of Methodologies in Academic and Community Settings

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• 作者：H. Bryant Nguyen ; Jason Oh ; Ronny M. Otero ; Kristy Burroughs ; William A. Wittlake ; Stephen W. Corbett
• 刊名：Journal of Emergency Medicine
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：38
• 期：2
• 页码：122-132
• 全文大小：777 K

文摘

Background: Evidence-based therapies for severe sepsis include early antibiotics, early goal-directed therapy, corticosteroids, recombinant human activated protein C, glucose control, and lung protective strategies. Objective: The objective of this study was to analyze methods, challenges, and outcomes observed by hospitals that implemented a hospital-wide sepsis management protocol incorporating evidence-based therapies. Methods: In a cross-sectional multi-center telephone survey over a 4-month period, clinicians (participants) responsible for developing a hospital sepsis protocol were questioned regarding its development and outcomes. Results: Participants completing surveys represented 40 hospitals (20 academic and 20 community). Twenty-seven percent of protocol champions were Emergency physicians or nurses. Sixty-three percent reported protocol development time of 6–12 months. Eighty-eight percent of participants reported protocol initiation in the Emergency Department. Three participants reported hiring a nurse educator to implement the protocol. Ninety-five percent of participants measure lactate as part of patient screening. Protocol therapies reported included early antibiotics (98 % ), early goal directed-therapy (EGDT) (98 % ), corticosteroids (80 % ), and activated protein C (73 % ). Contributions to success included having a protocol champion (85 % ) and sepsis education program (65 % ). Twenty-one participants had recorded patient-level data, totaling 2319 protocol patients, compared to 1719 non-protocol patients, with in-hospital mortality of 23 % and 44 % , respectively. Conclusions: Implementation of a sepsis management protocol incorporating evidence-based therapies can be accomplished in both academic and community hospitals, with minimal additional staffing. The presence of a protocol champion and education program is crucial to success, and may result in improved patient outcome.